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| 名称 | PC-3 (人前列腺癌细胞) (STR鉴定正确) |
| 别称 | PC3; PC.3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | PC-3细胞源于一位62岁白人男性Ⅳ级前列腺腺癌患者的骨头转移灶；PC-3细胞的酸性磷酸酶活性和5-α-睾丸激素还原酶活性都低。 |
| 年龄（性别） | 男性；62岁 |
| 组织来源 | 前列腺；骨腺癌转移灶 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 前列腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~25-50 hours |
| 致瘤性 | Yes, in semi-solid medium.Yes, tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 抗原表达情况 | HLA A1, A9 |
| 基因表达情况 | HLA A1, A9 |
| 保藏机构 | ATCC; CRL-1435 ATCC; CRL-7934DSMZ; ACC-465 ECACC; 90112714 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11 D2S1338 18,20 D3S1358 16 D5S818 13 D7S820 8,11 D8S1179 13 D13S317 11 D16S539 11 D18S51 14,15 D19S433 14 D21S11 29,31.2 FGA 24 PentaD 9 PentaE 10,17 TH01 6,7 TPOX 8,9 vWA 17 D6S1043 18 D12S391 21 D2S441 10,11 -
STR鉴定图
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参考文献
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Diterpenoid honatisine overcomes temozolomide resistance in glioblastoma by inducing mitonuclear protein imbalance through disruption of TFAM-mediated mtDNA transcription(2023/12/29)
作者：Zongyang Li, Ke Sai, Guoxu Ma
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.155328
影响因子 ：7.900
引用产品：CL-0185
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ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003(2023/12/04)
作者：Yupeng Wu, Wencai Zheng, Qi Huang
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04760-w
影响因子 ：7.400
引用产品：CL-0185
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Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5(2023/09/26)
作者：Pengming Pan, Tongtong Geng, Zhongtang Li
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c00864
影响因子 ：7.300
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Bimetallic Nanoplatform Dedicated to Sonodynamic-Calcium Overload Synergistic Therapy via Self-supplied Hydrogen Peroxide and Relieved Hypoxia(2023/12/12)
作者：Wenqian Xu, Yisheng Zhao, Chao Zhang
期刊：Biomaterials Science
影响因子 ：6.600
引用产品：CL-0185
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Risk subtyping and prognostic assessment of prostate cancer based on consensus genes(2022/03/15)
作者：Jialin Meng, Yu Guan, Bijun Wang
期刊：Communications Biology
DOI：10.1038/s42003-022-03164-8
影响因子 ：5.900
引用产品：CL-0185
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A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients(2023/03/14)
作者：Qi You, Jiayin Chen, Xiaohui Wu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.(2022/09/21)
作者：Longfei Yang, Yuwei Zhang, Yang Wang
期刊：Frontiers in Pharmacology
影响因子 ：5.600
引用产品：CL-0002 CL-0010 CL-0052 CL-0075 CL-0109 CL-0185 CL-0222 CL-0227 CM-H019 PM150110 PM150210 PM150910
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LOC100996425 acts as a promoter in prostate cancer by mediating hepatocyte nuclear factor 4A and the AMPK/mTOR pathway(2021/08/19)
作者：Xiuyan Wang, Bin Song, Mingcui Zang
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.300
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MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways(2021/11/10)
作者：Sihai Zhou, Zhihong Dai, Liang Wang
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.295
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177Lu-Labeled Bivalent Ligands of Prostate-Specific Membrane Antigen for Endoradiotherapy of Prostate Cancer(2023/12/28)
作者：Ruoxue Dai, Zhikai Cai, Rui Hu
期刊：MOLECULAR PHARMACEUTICS
DOI：10.1021/acs.molpharmaceut.3c00987
影响因子 ：4.900
引用产品：CL-0185
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Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer(2023/08/16)
作者：Hongzhuang Wen, Changbao Qu, Zhu Wang
期刊：FASEB JOURNAL
影响因子 ：4.800
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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance(2023/04/08)
作者：Longfei Yang, Yuwei Zhang, Yifan Tang
期刊：Scientific Reports
DOI：10.1038/s41598-023-27975-9
影响因子 ：4.600
引用产品：CL-0002 CL-0010 CL-0052 CL-0075 CL-0109 CL-0185 CL-0222 CL-0227 CM-H019 PM150110 PM150210 PM150910
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A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH(2019/03/27)
作者：Jin Li, Xiaokang Li, Jianbo Jia
期刊：Dyes And Pigments
DOI：10.1016/j.dyepig.2019.03.060
影响因子 ：4.500
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YAP1 inhibits RSL3-induced castration-resistant prostate cancer cell ferroptosis by driving glutamine uptake and metabolism to GSH(2023/09/29)
作者：Xian Fu, Hongshen Wu, Changjiu Li
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-023-04847-4
影响因子 ：4.300
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Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src(2021/10/28)
作者：Pei Cheng, Xiaofan Zhang, Xiaofu Wang
期刊：Endocrine
DOI：10.1007/s12020-021-02907-7
影响因子 ：3.925
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Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer(2023/06/10)
作者：Zelin Liu, Shuai Ke, Qinghua Wang
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113686
影响因子 ：3.700
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A cuproptosis-related LncRNA signature: Integrated analysis associated with biochemical recurrence and immune landscape in prostate cancer(2023/02/24)
作者：Lei Ren, Xu Yang, Weifeng Wang
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1096783
影响因子 ：3.700
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NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway(2020/3/28)
作者：Shengjun Luo, Lan Shao, Zhixiong Chen
期刊：Experimental Cell Research
DOI：10.1016/j.yexcr.2020.111981
影响因子 ：3.700
引用产品：CL-0185
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Crafting a Personalized Prognostic Model for Malignant Prostate Cancer Patients Using Risk Gene Signatures Discovered through TCGA-PRAD Mining, Machine Learning, and Single-Cell RNA-Sequencing(2023/06/07)
作者：Feng Lyu, Xianshu Gao, Mingwei Ma
期刊：Diagnostics
DOI：10.3390/diagnostics13121997
影响因子 ：3.600
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Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration‑resistant prostate cancer(2020/11/19)
作者：Mingqiu Hu, Jing Ning, Likai Mao
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0185
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Silencing of lncRNA MALAT1 inhibits cell cycle progression via androgen receptor signaling in prostate cancer cells(2019/1/7)
作者：Xiaofan Dai, Lingyun Liu, Zuowen Liang
期刊：Pathology Research And Practice
影响因子 ：2.800
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IU1 and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer(2023/08/07)
作者：Yifan Zhang, Yuanpeng Liao, Mayao Luo
期刊：PROSTATE
影响因子 ：2.800
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GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer(2022/10/25)
作者：Ming Yang, Xudong Zhu, Yang Shen
期刊：PeerJ
影响因子 ：2.700
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Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer(2023/04/12)
作者：Qingfu Zhang, Peng Zhang, Zhongting Zhao
期刊：PeerJ
影响因子 ：2.700
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TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible Factor-1α(2023/11/10)
作者：Kai Cheng, Qingmei Jia, Christopher Batbatan
期刊：JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
影响因子 ：2.300
引用产品：CL-0185
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Inhibitory function of CDK12i combined with WEE1i on castration-resistant prostate cancer cells in vitro and in vivo(2023/08/08)
作者：Zheng Qin, Dongze Liu, Yueyao Zhang
期刊：Oncologie
DOI：10.1515/oncologie-2023-0233
影响因子 ：0.900
