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  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)

HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)

货号:CL-0109

规格:1×10⁶cells/T25培养瓶

价格: ¥1600

生长培养基:MEM(含NEAA)10% FBS1% P/S

数量: - +

  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)

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HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确) HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
  • ¥1600
HK-2细胞专用培养基 HK-2细胞专用培养基
  • ¥350
  • ¥450

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产品概述
产品信息
名称 HK-2 (人肾皮质近曲小管上皮细胞) (STR鉴定正确)
别称 Hk-2; HK2; Human Kidney-2
背景描述 HK-2细胞属源于正常肾的近曲小管细胞,通过导入HPV-16 E6/E7基因而获得永生化。将含有HPV-16 E6/E7基因的重组的逆转录病毒载体pLXSN 16 E6/E7转染外生包装细胞Psi-2;Psi-2细胞产生的病毒再去感染兼嗜性包装细胞系PA317,最后将PA317细胞产生的病毒颗粒导入正常的肾皮质近曲小管细胞。尽管pLXSN 16 E6/E7中含有新霉素抗性,但未用G418筛选转导克隆。Southern和FISH分析显示,HK-2细胞来源于单克隆。PCR检测证实,HK-2细胞基因组中含有E6/E7基因。
种属
年龄(性别) 成年
组织来源 肾,皮质/近端小管
生长特性 贴壁细胞
细胞形态 上皮细胞样
细胞类型 转化细胞系
生物安全等级 2
生长培养基 MEM(含NEAA)10% FBS1% P/S
推荐传代比例 1:2-1:4
推荐换液频率 2~3次/周
冻存条件 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮
培养条件 气相:空气,95%;CO2,5% 温度:37℃
受体表达情况 epidermal growth factor (EGF), expressed
基因表达情况 alkaline phosphatase; gamma glutamyltranspeptidase; leucine aminopeptidase; acid phosphatase; cytokeratin; alpha 3, beta 1 integrin; fibronectin
保藏机构 ATCC; CRL-2190 BCRC; 60097
STR鉴定
  • STR位点信息
    Amelogenin X
    CSF1PO 13
    D2S1338 17,25
    D3S1358 16
    D5S818 12
    D7S820 10,11
    D8S1179 10,14
    D13S317 9
    D16S539 12
    D18S51 12
    D19S433 15,15.2
    D21S11 28,30
    FGA 20
    PentaD 9,12
    PentaE 10,11
    TH01 9
    TPOX 8,9
    vWA 17,18
    D6S1043 12,13
    D12S391 17.3,22
    D2S441 11,12
  • STR鉴定图
参考文献
文献列表
  • A calcium phosphate drug carrier loading with 5-fluorouracil achieving a synergistic effect for pancreatic cancer therapy(2021/07/20)

    作者:Junzong Chen, Miaojuan Qiu, Shiqiang Zhang

    期刊:Journal Of Colloid And Interface Science

    DOI:10.1016/j.jcis.2021.07.080

    影响因子 :9.965

    引用产品:CL-0109

  • ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway(2020/08/22)

    作者:Zhida Chen, Chunying Wu, Yuting Liu

    期刊:Cell Death & Disease

    DOI:10.1038/s41419-020-02912-0

    影响因子 :9.685

    引用产品:CL-0109

  • Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis(2021/09/11)

    作者:Bo Zhang, Xiang Chen, Feng Ru

    期刊:Cell Death & Disease

    DOI:10.1038/s41419-021-04137-1

    影响因子 :9.685

    引用产品:CL-0109

  • Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling(2021/11/26)

    作者:Kai Xue,Yurong Wang,Yan Wang

    期刊:Oxidative Medicine and Cellular Longevity

    DOI:10.1155/2021/5710440

    影响因子 :7.3100

    引用产品:164210 164210-50 CL-0109 PB180120 PM150312

  • A nanosensor for precise discrimination of nephrotoxic drug mechanisms via dynamic fluorescence fingerprint strategy(2021/03/20)

    作者:Xiean Yu, Xuefei Bai, Ran Zhang

    期刊:Analytica Chimica Acta

    DOI:10.1016/j.aca.2021.338447

    影响因子 :6.911

    引用产品:CL-0109 PB180424

  • Involvement of miR‐27a‐3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress(2020/07/21)

    作者:Lina Wu, Qingzhu Wang, Feng Guo

    期刊:Journal Of Cellular Physiology

    DOI:10.1002/jcp.29951

    影响因子 :6.513

    引用产品:CL-0109

  • Migration of Human Renal Tubular Epithelial Cells in Response to Physiological Electric Signals(2021/09/14)

    作者:Linbo Guan, Ping Fan, Xinghui Liu

    期刊:Frontiers in Cell and Developmental Biology

    DOI:10.3389/fcell.2021.724012

    影响因子 :6.081

    引用产品:CL-0001 CL-0109

  • Senkyunolide I alleviates renal Ischemia-Reperfusion injury by inhibiting oxidative stress, endoplasmic reticulum stress and apoptosis(2021/11/30)

    作者:Yalin Zhu, Jie Huang, Xueying Chen

    期刊:International Immunopharmacology

    DOI:10.1016/j.intimp.2021.108393

    影响因子 :5.7140

    引用产品:164210 164210-50 CL-0109 PB180120 PM150410

  • Sodium butyrate ameliorates deoxycorticosterone acetate/salt-induced hypertension and renal damage by inhibiting the MR/SGK1 pathway(2020/9/9)

    作者:Chunying Wu, Zhida Chen, Linlin Zhang

    期刊:Hypertension Research

    DOI:10.1038/s41440-020-00548-3

    影响因子 :5.5280

    引用产品:CL-0109 PB180120

  • Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury(2021/1/19)

    作者:Heyun Li, Xia Zhang, Peng Wang

    期刊:Diabetology & Metabolic Syndrome

    DOI:10.1186/s13098-021-00625-8

    影响因子 :5.3950

    引用产品:CL-0109

  • Rapid and sensitive detection of NGAL for the prediction of acute kidney injury via a polydopamine nanosphere/aptamer nanocomplex coupled with DNase I-assisted recycling amplification(2020/04/01)

    作者:Yiting Hu, Xie an Yu, Ying Zhang

    期刊:Analyst

    DOI:10.1039/D0AN00474J

    影响因子 :5.227

    引用产品:CL-0109

  • Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylgphloroglucinol from Rhodomyrtus tomentosa(2018/9/7)

    作者:Liyun Zhao, Hongxin Liu, Lei Wang

    期刊:Journal Of Ethnopharmacology

    DOI:10.1016/j.jep.2018.09.011

    影响因子 :5.1950

    引用产品:CL-0109

  • Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway(2021/07/24)

    作者:Mengyuan Qin, Songqing Huang, Xiaoqin Zou

    期刊:Journal Of Ethnopharmacology

    DOI:10.1016/j.jep.2021.114414

    影响因子 :5.195

    引用产品:CL-0109

  • MicroRNA 181a-2-3p Alleviates the Apoptosis of Renal Tubular Epithelial Cells via Targeting GJB2 in Sepsis-Induced Acute Kidney Injury | Molecular and Cellular Biology(2021/6/23)

    作者:Huixing Yi, Shouyin Jiang, Linghua Yu

    期刊:Molecular And Cellular Biology

    DOI:10.1128/MCB.00016-21

    影响因子 :5.0690

    引用产品:CL-0109

  • Efficacy of Obcordata A from Aspidopterys obcordata on Kidney Stones by Inhibiting NOX4 Expression(2019/03/21)

    作者:Yihang Li, Guoxu Ma, Yana Lv

    期刊:Molecules

    DOI:10.3390/molecules24101957

    影响因子 :4.927

    引用产品:CL-0109

  • Anti-Malignant Ascites Effect of Total Diterpenoids from Euphorbiae ebracteolatae Radix Is Attributable to Alterations of Aquaporins via Inhibiting PKC Activity in the Kidney(2021/02/10)

    作者:Yuanbin Zhang, Dongfang Liu, Fan Xue

    期刊:Molecules

    DOI:10.3390/molecules26040942

    影响因子 :4.927

    引用产品:164210 164210-50 CL-0109

  • Efficacy of Obcordata A from Aspidopterys obcordata on Kidney Stones by Inhibiting NOX4 Expression(2019/5/21)

    作者:Yihang Li, Guoxu Ma, Yana Lv

    期刊:Molecules.

    DOI:10.3390/molecules24101957.

    影响因子 :4.9270

    引用产品:CL-0109

  • The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study(2021/11/10)

    作者:Fangshi Xu, Yibing Guan, Li Xue

    期刊:Cancer Medicine

    DOI:10.1002/cam4.4395

    影响因子 :4.7110

    引用产品:CL-0010 CL-0109 CL-0254

  • Pan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma(20220/2/16)

    作者:Yiguan Qian, Yang Li, Ke Chen

    期刊:Journal of Inflammation Research

    DOI:10.2147/JIR.S347732

    影响因子 :4.631

    引用产品:CL-0009 CL-0010 CL-0021 CL-0052 CL-0109

  • Metabolomics analysis underlay mechanisms in the renal impairment of mice caused by combination of aflatoxin M1 and ochratoxin A(2021/06/11)

    作者:Ziwei Wang, Yanan Gao, Xin Huang

    期刊:Toxicology

    DOI:10.1016/j.tox.2021.152835

    影响因子 :4.571

    引用产品:CL-0109

  • Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling(2021/07/15)

    作者:Qiang Zheng, Hang Zhao, Dong Jia

    期刊:Mediators Of Inflammation

    DOI:10.1155/2021/5571272

    影响因子 :4.529

    引用产品:CL-0109

  • HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma(2021/2/19)

    作者:Yuanbo Cui, Chunyan Zhang, Ya Li

    期刊:Cell Biology International

    DOI:10.1002/cbin.11568

    影响因子 :4.4730

    引用产品:CL-0010 CL-0052 CL-0109 CL-0254

  • δ‐Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β‐catenin nuclear localization and activating its downstream target genes(2020/1/28)

    作者:Lincheng Ju, Liping Shan, Bo Yin

    期刊:Cancer Medicine

    DOI:10.1002/cam4.2857

    影响因子 :4.4520

    引用产品:CL-0109

  • Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma(2020/05/22)

    作者:Yuanbo Cui, Ming Yan, Chunyan Zhang

    期刊:Journal of Cancer Research and Clinical Oncology

    DOI:10.1007/s00432-020-03259-x

    影响因子 :4.322

    引用产品:CL-0010 CL-0052 CL-0109 CL-0254

  • Downregulation of IRF2 Alleviates Sepsis-Related Acute Kidney Injury in vitro and in vivo(2021/12/22)

    作者:Yanyan Zhang, Yun Zhang, Aixiang Yang

    期刊:Drug Design Development and Therapy

    DOI:10.2147/DDDT.S334518

    影响因子 :4.3190

    引用产品:CL-0109

  • (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells(2017/12/8)

    作者:Hui Fang, Chuanming Xu, Aihua Lu

    期刊:Am J Physiol Cell Physiol

    DOI:10.1152/ajpcell.00006.2017: 10.1152/ajpcell.00006.2017

    影响因子 :4.2490

    引用产品:CL-0109

  • Soluble (pro)renin receptor promotes the fibrotic response in renal proximal tubule epithelial cells in vitro via the Akt/β-catenin/Snail signaling pathway(2020/11/1)

    作者:Shiying Xie, Jiahui Su, Aihua Lu

    期刊:American Journal Of Physiology-Renal Physiology

    DOI:10.1152/ajprenal.00197.2020

    影响因子 :3.3770

    引用产品:CL-0109

  • Circular RNA circ_0068,888 protects against lipopolysaccharide-induced HK-2 cell injury via sponging microRNA-21–5p(2021/2/12)

    作者:Wei Wei, Yuanyuan Yao, Hongyuan Bi

    期刊:Biochemical And Biohysical Research Communicattons

    DOI:10.1016/j.bbrc.2020.12.018.

    影响因子 :3.3220

    引用产品:CL-0109

  • MiR-32-5p knockdown inhibits epithelial to mesenchymal transition and renal fibrosis by targeting SMAD7 in diabetic nephropathy:(2020/09/22)

    作者:H-J Wang, H Liu, Y-H Lin

    期刊:Human & Experimental Toxicology

    DOI:10.1177/0960327120952157

    影响因子 :3.2470

    引用产品:CL-0109

  • Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation( 2019/11/21)

    作者:Huaxin Wang, Xuan Peng, Yayi Huang

    期刊:Yonsei Med J

    DOI:10.3349/ymj.2019.60.12.1195

    影响因子 :3.0520

    引用产品:CL-0109

  • Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury(2021/10/26)

    作者:Peng Ke, Lin Qian, Yi Zhou

    期刊:PeerJ

    DOI:10.7717/peerj.12375

    影响因子 :2.9840

    引用产品:CL-0109

  • CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA(2021/12/13)

    作者:Fu Wang, Fangfang Zhang, Qiangqiang Tian

    期刊:Autoimmunity

    DOI:10.1080/08916934.2021.2012764

    影响因子 :2.9570

    引用产品:164210 164210-50 CL-0109 PB180120

  • Thioredoxin relieves lipopolysaccharide‑induced acute kidney injury in mice by reducing inflammation, oxidative stress and apoptosis(2021/4/15)

    作者:Jingjing Wang, Wenjuan Zhang, Guoyuan Lu

    期刊:Experimental and Therapeutic Medicine

    DOI:10.3892/etm.2021.10061.

    影响因子 :2.7510

    引用产品:CL-0109

  • Long Non-Coding RNA CASC2 Overexpression Ameliorates Sepsis-Associated Acute Kidney Injury by Regulating MiR-545-3p/PPARA axis(2021/05/03)

    作者:Qionghua Hu, Weiwei Zen, Ming Zhang

    期刊:Journal of Surgical Research

    DOI:10.1016/j.jss.2021.03.047

    影响因子 :2.4170

    引用产品:CL-0001 CL-0109

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