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| 名称 | PANC-1 (人胰腺癌细胞) (STR鉴定正确) |
| 别称 | Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P |
| 背景描述 | 这株人胰腺癌细胞株PANC-1源自于胰腺癌导管细胞。PANC-1细胞倍增时间为52小时，G6PD活性处于低泳动性的B型。染色体研究表明，PANC-1细胞模式数目为63，包括3个独特标记的染色体和1个小环状染色体。PANC-1细胞的生长可被1U/ml的左旋天冬酰胺酶抑制；PANC-1细胞能在软琼脂上生长，亦能在裸鼠上成瘤。 |
| 种属 | 人 |
| 年龄（性别） | 男；56岁 |
| 组织来源 | 胰腺；胰管；上皮细胞癌 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | DMEM＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~38-56 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 保藏机构 | ATCC; CRL-1469 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 23,24 D3S1358 17 D5S818 11,13 D7S820 8,10 D8S1179 14,15 D13S317 11 D16S539 11 D18S51 12 D19S433 11,16 D21S11 28 FGA 21 PentaD 14 PentaE 7,14 TH01 7,8 TPOX 8,11 vWA 15 D6S1043 11,12 D12S391 22 D2S441 10,14 -
STR鉴定图
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参考文献
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway(2022/04/07)
作者：Ma Zuyi, Li Zhenchong, Wang Shujie
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02310-8
影响因子 ：12.6580
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Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription(2022/02/18)
作者：Weiwei Yang , Jing Li, Minghui Zhang
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-022-02260-1
影响因子 ：12.658
引用产品：CL-0016 CL-0041 CL-0097 CL-0101 CL-0114 CL-0184 CL-0215 CL-0525
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SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis(2021/07/24)
作者：Dianyun Ren, Yan Sun, Dan Zhang
期刊：Cancer Letters
DOI：10.1016/j.canlet.2021.07.035
影响因子 ：9.756
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Simultaneous Fluorescence Visualization of Epithelial-Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial-Mesenchymal Transition on Drug Efficacy(2018/09/18)
作者：Mingming Luan, Jinjie Chang, Wei Pan
期刊：Anal Chem
DOI：10.1021/acs.analchem.8b02494
影响因子 ：8.008
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Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research(2022/01/08)
作者：Zhenghai Bai, Fangshi Xu, Xiaodan Feng
期刊：Bioengineered
DOI：10.1080/21655979.2021.2019873
影响因子 ：6.8320
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A gold–selenium-bonded nanoprobe for real-time in situ imaging of the upstream and downstream relationship between uPA and MMP-9 in cancer cells(2019/03/16)
作者：Mingming Luan
期刊：Chem Commun
影响因子 ：6.065
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Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis(2021/11/19)
作者：Yuan Chi, He Xin, Zhaoyu Liu
期刊：Frontiers in Oncology
影响因子 ：5.7380
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MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation(2020/01/21)
作者：Wenjie Huang, Jianyou Gu, Tian Tao
期刊：Frontiers in Oncology
影响因子 ：5.738
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway(2020/3/10)
作者：Xiangpeng Meng, Jia Ma, Baosheng Wang
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-020-00734-4
影响因子 ：5.0800
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A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation(2021/11/22)
作者：Chao Wu, Zhihong Huang, Ziqi Meng
期刊：Chinese Medicine
DOI：10.1186/s13020-021-00534-y
影响因子 ：4.5460
引用产品：CL-0184
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CMTM3 Overexpression Predicts Poor Survival and Promotes Proliferation and Migration in Pancreatic Cancer(2021/08/03)
作者：Zixuan Zhou, Zuyi Ma, Zhenchong Li
期刊：Journal of Cancer
影响因子 ：4.478
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Targeting the EZH2-PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer(2021/7/22)
作者：Jilong Hu, Zhinan Zheng, Jia Lei
期刊：PPAR Research
影响因子 ：4.3850
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TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation(2021/2/19)
作者：Yuanbo Cui, Chunyan Zhang, Shanshan Ma
期刊：Biological Chemistry
影响因子 ：3.9150
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Transcriptome analysis of pancreatic cancer cell response to treatment with grape seed proanthocyanidins(2018/12/6)
作者：Weihua Wang, Leilei Zhan, Dongqi Guo
期刊：Oncology Letters
影响因子 ：3.1110
引用产品：CL-0184
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Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum(2020/11/12)
作者：Xiao Wu, Liping Jiang, Zeng Zhang
期刊：Oncology Letters
影响因子 ：3.1110
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Grape seed proanthocyanidins inhibit proliferation of pancreatic cancer cells by modulating microRNA expression(2019/1/4)
作者：Weihua Wang, Leilei Zhan, Dongqi Guo
期刊：Oncology Letters
影响因子 ：3.1110
引用产品：CL-0184
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Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells(2020/5/20)
作者：Lei Zhang, Zhenyong Wang, Deshuai Kong
期刊：Bioscience Biotechnology And Biochemistry
DOI：10.1080/09168451.2020.1762479
影响因子 ：2.3370
