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产品概述
名称 | BT-549 (人乳腺管癌细胞) (STR鉴定正确) |
别称 | BT 549; BT.549; BT549 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
生长培养基 | RPMI-1640+10% FBS+10μg/mL Insulin+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2~3次/周 |
背景描述 | BT-549细胞的来源组织是一个乳头状侵入性导管瘤,7个局部淋巴结中3个已有转移。由此组织建立的BT-549细胞是多态性的,包括上皮细胞样组分和多核巨细胞。 |
年龄(性别) | 女;72岁 |
组织来源 | 乳腺 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 乳腺癌细胞 |
生物安全等级 | 1 |
倍增时间 | ~54-90 hours |
保藏机构 | ATCC; HTB-122 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 17 D3S1358 18 D5S818 11 D7S820 9,10 D8S1179 14,16 D13S317 11 D16S539 8 D18S51 15 D19S433 15.2 D21S11 32.2 FGA 19 PentaD 13 PentaE 14 TH01 9.3 TPOX 8 vWA 15,18 D6S1043 11 D12S391 18,20 D2S441 11.3 -
STR鉴定图
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参考文献
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Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription(2022/02/18)
作者:Weiwei Yang , Jing Li, Minghui Zhang
期刊:Journal Of Experimental & Clinical Cancer Research
DOI:10.1186/s13046-022-02260-1
影响因子 :11.300
引用产品:CL-0016 CL-0041 CL-0097 CL-0101 CL-0114 CL-0184 CL-0215 CL-0525
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PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis(2023/06/01)
作者:Zhe Wang, Ruolei Li, Niuniu Ho
期刊:Journal for ImmunoTherapy of Cancer
影响因子 :10.900
引用产品:CL-0007 CL-0041 CL-0093 CL-0149 CL-0211 CL-0228 CL-0525 CM-0007 CM-0041 CM-0093 CM-0149 CM-0211 CM-0228 CM-0525
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Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer(2021/4/19)
作者:Xinxing Wang, Bingjian Xue, Yujie Zhang
期刊:Cell Death & Disease
DOI:10.1038/s41419-021-03684-x
影响因子 :9.000
引用产品:CL-0040 CL-0041 CL-0149 CL-0150A CL-0150B CL-0152A CL-0152B CL-0290A CL-0290B CL-0525
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MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis(2021/04/06)
作者:Fengxia Chen, Qingqing Wang, Xiaoyan Yu
期刊:Cell Death & Disease
DOI:10.1038/s41419-021-03661-4
影响因子 :9.000
引用产品:CL-0005 CL-0041 CL-0114 CL-0150A CL-0150B CL-0380 CL-0525 PM150312B
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A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells(2021/03/19)
作者:Ying Ma, Jun Weng, Ning Wang
期刊:International Journal Of Biological Macromolecules
DOI:10.1016/j.ijbiomac.2021.03.101
影响因子 :8.200
引用产品:CL-0041
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Calycosin inhibits triple-negative breast cancer cells progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway(2023/06/14)
作者:Yuhong Li, Shuying Hu, Yueqi Chen
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2023.154924
影响因子 :7.900
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Low Dose of Paclitaxel Combined with XAV939 Attenuates Metastasis, Angiogenesis and Growth in Breast Cancer by Suppressing Wnt Signaling(2019/08/14)
作者:Dattatrya Shetti, Bao Zhang
期刊:Cells
影响因子 :6.000
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Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway(2023/03/17)
作者:Yanting You, Xiaomei Chen, Xiaohu Chen
期刊:JOURNAL OF ETHNOPHARMACOLOGY
影响因子 :5.400
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Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis | Molecular and Cellular Biology(2021/9/24)
作者:Yihong Huang, Shuo Zheng, Ying Lin, Liming Kea
期刊:Molecular And Cellular Biology
影响因子 :5.300
引用产品:164210 CL-0041 CL-0150A CL-0152A CL-0290A CL-0525 PB180120 PM150110 PM151010
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The curcumin analog EF24 inhibits proliferation and invasion of triple-negative breast cancer cells by targeting the lncRNA HCG11/Sp1 axis | Molecular and Cellular Biology(2021/11/15)
作者:Yin Duan, Huiling Chen, Min Ling
期刊:Molecular And Cellular Biology
影响因子 :5.300
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Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner(2021/10/27)
作者:Jianjun Wang, Kunxian Yang, Junyu Cao
期刊:Bioengineered
DOI:10.1080/21655979.2021.2000731
影响因子 :4.900
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The inhibition of centromere protein K causes anticancer effects in breast carcinoma via effects on the FAK/PI3K/AKT/mTOR pathway(2022/09/09)
作者:Jiao Yu, Kai Wang, Sanhu Yang
期刊:TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI:10.1016/j.taap.2022.116232
影响因子 :3.800
引用产品:CL-0041 CL-0114 CL-0149 CL-0228 CL-0324 CL-0525 PM150110 PM150312 PM150411
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MiR‐96‐5p promotes breast cancer migration by activating MEK/ERK signaling(2020/2/2)
作者:Weiyan Qin, Shichun Feng, Yongqiang Sun
期刊:Journal Of Gene Medicine
DOI:10.1002/jgm.3188
影响因子 :3.500
引用产品:CL-0041
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LncRNA AFAP1-AS1 Knockdown Represses Cell Proliferation, Migration, and Induced Apoptosis in Breast Cancer by Downregulating SEPT2 Via Sponging miR-497-5p(2020/9/21)
作者:Bo Cai, Xichao Wang, Qingao Bu
期刊:Cancer Biother And Radiopharm
影响因子 :3.400
引用产品:CL-0041
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p53 downregulates PD-L1 expression via miR-34a to inhibit the growth of triple-negative breast cancer cells: a potential clinical immunotherapeutic target(2022/11/09)
作者:Deng, Siyu, Wang, Mengna, Wang, Chenglong, Zeng, Yan, Qin, Xue, Tan, Yiwen, Liang, Bing, Cao, Youde
期刊:MOLECULAR BIOLOGY REPORTS
DOI:10.1007/s11033-022-08047-z
影响因子 :2.800
引用产品:CL-0041
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Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758–3p to promote the development of breast cancer(2022/11/08)
作者:Huaqing Ou, Jialing Li, Qinhua Lv, Decai Feng
期刊:Reproductive Biology
DOI:10.1016/j.repbio.2022.100708
影响因子 :2.100
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FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo(2023/06/19)
作者:Wenyu Li, Hu Liu, Wenjuan Li
期刊:Molecular & Cellular Toxicology
DOI:10.1007/s13273-023-00368-9
影响因子 :1.700
引用产品:164215 CL-0041 CL-0150B CL-0290B CL-0383B CL-0525 PB180120 PM150110 PM150210 PM150312
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SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells(2020/11/24)
作者:Ning Wang, Jun Weng, Jing Xia
期刊:Stem Cell Research
影响因子 :1.200
引用产品:CL-0041