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名称 | A-498 (人肾癌细胞) (STR鉴定正确) |
别称 | A498 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
生长培养基 | MEM(含NEAA)+10% FBS+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2~3次/周 |
背景描述 | A-498细胞是由Aaronson·S建立,源自一位52岁患有肾癌的女性病人。 |
年龄(性别) | 女;52岁 |
组织来源 | 肾脏 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肾癌细胞 |
生物安全等级 | 1 |
倍增时间 | ~60 hours |
致瘤性 | Yes, in nude mice; forms undifferentiated carcinoma; also forms tumors in anti thymocyte serum treated newborn mice. |
保藏机构 | ATCC; CRL-7908ATCC; HTB-44 DSMZ; ACC-55 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 26 D3S1358 15 D5S818 11,13 D7S820 10,11 D8S1179 13,15 D13S317 12 D16S539 12 D18S51 17 D19S433 12 D21S11 28,32 FGA 18,20 PentaD 9,14 PentaE 10,14 TH01 6,9.3 TPOX 8,11 vWA 18 D6S1043 11 D12S391 21 D2S441 11,14 -
STR鉴定图
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参考文献
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ZDHHC2-mediated AGK palmitoylation activates AKT/mTOR signaling to reduce sunitinib sensitivity in renal cell carcinoma(2023/04/20)
作者:Yan Sun, Liang Zhu, Pian Liu
期刊:CANCER RESEARCH
DOI:10.1158/0008-5472.CAN-22-3105
影响因子 :11.500
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55(2020/12/01)
作者:Jiafu Feng, Yongcan Guo, Yuanmeng Li
期刊:Journal Of Experimental & Clinical Cancer Research
DOI:10.1186/s13046-020-01744-2
影响因子 :11.300
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YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway(2022/08/17)
作者:Wei Li, Kun Ye, Xurui Li
期刊:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI:10.1186/s13046-022-02460-9
影响因子 :11.300
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming(2023/02/20)
作者:Zhangnan Liu, Mengzhen Fan, Junqing Hou
期刊:Cell Death & Disease
DOI:10.1038/s41419-023-05677-4
影响因子 :9.000
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The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis(2023/02/02)
作者:Yapeng Wang, Mou Peng, Yawen Zhong
期刊:ONCOGENE
DOI:10.1038/s41388-023-02613-w
影响因子 :8.000
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RETRACTED ARTICLE: Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205(2020/2/19)
作者:Ludong Zhang, Ya Guo
期刊:Artificial Cells Nanomedicine and Biotechnology
DOI:10.1080/21691401.2020.1725532
影响因子 :5.800
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δ‐Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β‐catenin nuclear localization and activating its downstream target genes(2020/01/28)
作者:Lincheng Ju, Liping Shan, Bo Yin
期刊:Cancer Medicine
影响因子 :4.000
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The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study(2021/11/10)
作者:Fangshi Xu, Yibing Guan, Li Xue
期刊:Cancer Medicine
影响因子 :4.000
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma(2021/2/19)
作者:Yuanbo Cui, Chunyan Zhang, Ya Li
期刊:Cell Biology International
影响因子 :3.900
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma(2020/05/22)
作者:Yuanbo Cui, Ming Yan, Chunyan Zhang
期刊:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI:10.1007/s00432-020-03259-x
影响因子 :3.600
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Construction and Validation of a Novel Cuproptosis-Related Seven-lncRNA Signature to Predict the Outcomes, Immunotherapeutic Responses, and Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma(2023/01/25)
作者:Haoxun Zhang, Zikuan Ning, Bowen Wang
期刊:DISEASE MARKERS
影响因子 :3.464
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Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma(2021/09/20)
作者:Peipei Han, Yifang Wang, Wenqi Luo
期刊:Pathology Research And Practice
影响因子 :3.309
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APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells(2021/3/17)
作者:Hua Xia, Yamin Liu, Lei Xu
期刊:IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
DOI:10.1007/s11626-021-00589-z.
影响因子 :2.100
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Identification of a combined lncRNA prognostic signature and knockdown of lncRNA MANCR to inhibit progression of clear cell renal cell carcinoma by bioinformatics analysis(2022/09/01)
作者:Sheng Xue, Hanxu Guo, Shibo Wei
期刊:Translational Andrology and Urology
影响因子 :2.000