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产品概述
| 名称 | MG-63 (人骨肉瘤细胞) (STR鉴定正确) |
| 别称 | M-G63; MG63 |
| 背景描述 | MG-63细胞源自14岁患有骨肉瘤的白人男性；聚次黄嘌呤核苷-聚胞嘧啶核苷酸、放线菌酮和放线菌素D可以诱导MG-63细胞产生高水平的干扰素。MG-63细胞表达TGF-β受体Ⅰ和Ⅱ。 |
| 种属 | 人 |
| 年龄（性别） | 男；14岁 |
| 组织来源 | 骨；骨肉瘤 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肉瘤细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | MEM（含NEAA）＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~28-38 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 受体表达情况 | transforming growth factor beta (TGF-beta) RI, expressed;transforming growth factor beta (TGF-beta) RII, expressed |
| 基因表达情况 | interferon |
| 保藏机构 | ATCC; CRL-1427 ECACC; 86051601 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 17,24 D3S1358 15 D5S818 11,12 D7S820 10 D8S1179 13 D13S317 11 D16S539 11 D18S51 16 D19S433 13,14 D21S11 30 FGA 21,25 PentaD 9,13 PentaE 11,12 TH01 9.300000000000001 TPOX 8,11 vWA 16,19 D6S1043 12,17 D12S391 15,20 D2S441 10,11 -
STR鉴定图
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参考文献
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Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects(2022/10/26)
作者：Yao Zhao, Xu Peng, Xiaoyang Xu
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2022.120264
影响因子 ：10.7230
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Macroscopic Supramolecular Assembly Strategy to Construct 3D Biocompatible Microenvironments with Site-Selective Cell Adhesion(2021/06/11)
作者：Changyu Wang, Cuiling Lin, Rui Ming
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression(2021/08/26)
作者：Lei Ding, Taiyuan Liu, Yuan Qu
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.08.022
影响因子 ：10.183
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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells(2021/10/18)
作者：Yi Luo, Xu Gao, Luetao Zou
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.310
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Verification of Ferroptosis Subcluster-Associated Genes Related to Osteosarcoma and Exploration of Immune Targeted Therapy(2022/09/28)
作者：Mingyang Jiang, Yiji Jike, Fu Gan
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3100
引用产品：CL-0157
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Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect(2022/11/17)
作者：Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xiaohui Chen, Xu He, Yue Wu, Xiangchen Zeng, Yuting Yueh, Ren Xu, Guangrong Ji
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
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Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/β-catenin pathway and is upregulated by miR-940 in osteosarcoma(2022/03/17)
作者：Shuhong Liang, Xiaojian Zhang, Jun Li
期刊：Bioengineered
DOI：10.1080/21655979.2022.2040827
影响因子 ：6.8320
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9(2021/07/14)
作者：Weihang Li, Ziyi Ding, Dong Wang
期刊：Cancer Cell International
DOI：10.1186/s12935-021-02041-4
影响因子 ：6.429
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy(2019/08/07)
作者：Hongliang Ying, Boda Ying, Jinrui Zhang
期刊： Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影响因子 ：6.355
引用产品：CL-0157
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy(2019/08/07)
作者：Hongliang Ying, Boda Ying, Jinrui Zhang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影响因子 ：6.355
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RNA-Sequence Reveals the Regulatory Mechanism of miR-149 on Osteoblast Skeleton under Mechanical Tension(2022/09/23)
作者：Yifan Wang, Guanyin Zhu, Fang Pei
期刊：Stem Cells International
影响因子 ：5.1310
引用产品：CL-0157
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Down-regulation of PRR11 affects the proliferation, migration and invasion of osteosarcoma by inhibiting the Wnt/β-catenin pathway(2021/09/13)
作者：Ke Li, Hongtao Yu, Chunbing Zhao
期刊：Journal of Cancer
影响因子 ：4.478
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Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis(2020/5/7)
作者：Ling Liu, Shuya Wang
期刊：OncoTargets and Therapy
影响因子 ：4.3450
引用产品：CL-0157
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The effect of resolvin D1 on bone regeneration in a rat calvarial defect model(2022/08/18)
作者：Xiaofeng Jiang, Jing Liu, Si Li
期刊：Journal of Tissue Engineering and Regenerative Medicine
影响因子 ：4.3230
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3D printed porous PLA/nHA composite scaffolds with enhanced osteogenesis and osteoconductivity in vivo for bone regeneration(2019/09/09)
作者：Xibao Chen, Chunxia Gao, Jiawei Jiang
期刊：Biomedical Materials
影响因子 ：4.103
引用产品：CL-0157
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Enterococcus faecalis OG1RF induces apoptosis in MG63 cells via caspase-3/-8/-9 without activation of caspase-1/GSDMD(2021/8/9)
作者：Yang Li, Cheng Wen, Jialin Zhong
期刊：Oral Diseases
影响因子 ：3.5110
引用产品：CL-0157
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Nanoscale Au@SiO2‑drug/VEGF as an in vivo probe for osteosarcoma diagnosis and therapy(2021/9/8)
作者：Tiangui Chen, Tianbo Li, Jiangning Wang
期刊：Oncology Letters
影响因子 ：2.9670
引用产品：CL-0157
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PROSER2 is a poor prognostic biomarker for patients with osteosarcoma and promotes proliferation, migration and invasion of osteosarcoma cells(2022/11/08)
作者：Zhengjiang Li, Yan Zhang, Yongkui Li, Shuxing Xing, Shunqiang Li, Jing Lyu, Zhaonan Ban
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7510
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Lithium-incorporated deproteinized bovine bone substitute improves osteogenesis in critical-sized bone defect repair:(2018/4/19)
作者：Hongzhang Guo, Changde Wang, Jixiang Wang
期刊：Journal Of Biomaterials Applications
影响因子 ：2.7120
引用产品：CL-0157
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Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner(2021/12/20)
作者：Tehasi Wang, Chengguang Zhang, Shuren Wang
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-021-02868-7
影响因子 ：2.6770
